Themen:
- Kritik – Sacubitril/Valsartan
- Effectiveness of Foot Orthoses Versus Corticosteroid Injection for Plantar Heel Pain
- Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women
- Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Severe Urinary Tract Infections
- Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts
- Sekundärprävention mit Statien im hohen Lebensalter
Generelle Probleme: Rasche Zulassung – 2014 Phase-III-Studie, 2015 Zulassung (FDA, EMA), 2016 in US-LL (ACC/AHA/HFSA) und in EU/DE-LL (ESC, NVL) für HI https://clinicaltrials.gov/ct2/show/NCT01035255 https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshot-entresto https://www.ema.europa.eu/en/medicines/human/EPAR/entresto https://www.ahajournals.org/doi/pdf/10.1161/CIR.0000000000000435 https://academic.oup.com/eurheartj/article/37/27/2129/1748921 Sicherheitsbedenken – Hypotonie+Angioödeme häufiger als bei ACEH, bisherige ARNI wg deutlichem Angioödem-Potenzial nicht ...
EvidenceAlerts Effectiveness of Foot Orthoses Versus Corticosteroid Injection for Plantar Heel Pain: Whittaker GA, Munteanu SE, Menz HB, et al. The SOOTHE Randomized Clinical Trial.J Orthop Sports Phys Ther. 2019 Jul;49(7):491-500. doi: 10.2519/jospt.2019.8807. Epub 2019 May 26. Abstract BACKGROUND Plantar ...
Abstract (gekürzt auf das Wesentliche) Objectives To assess the effects of intermittent oral iron supplementation, alone or in combination with other nutrients, on anaemia and its associated impairments among menstruating women, compared with no intervention, a placebo, or daily supplementation ...
McMaster Dave CV, Schneeweiss S, Kim D, et al. Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Severe Urinary Tract Infections: A Population-Based Cohort Study. Ann Intern Med. 2019 Jul 30. pii: 2739786. doi: 10.7326/M18-3136. (Original study) Hintergrund: Frühere Studien berichteten ...
Diabetes Care 2019 Jun; 42(6): 1095-1103. OBJECTIVE Topical corticosteroids (CSs) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. Although topical CS package inserts describe hyperglycemia and glycosuria as adverse drug reactions, it is unclear whether topical ...
Arzneitelegramm Die Daten aus randomisierten kontrollierten Studien zur Sekundärprävention sprechen nicht für einen Rückgang der Effektivität von Statinen im Alter. Das Risiko kardiovaskulärer Erkrankungen nimmt jedoch mit dem Alter zu. Alter allein sollte daher unseres Erachtens kein Grund sein, Statine ...