Imaging is a powerful tool for the early detection of cancer and the concomitant increase of patient survival time. The low incidence of cancer in asymptomatic individuals hampers the use of imaging techniques, as the vast majority of imaging results show the absence of cancer. In a prospective, non-interventional study, 5.114 asymptomatic individuals between 50 to 70 years of age who had no personal history of cancer within the last eight years were analyzed with the so called PanTum Detect blood test, which is based on phagocytosis and elimination of tumor cells by CD14 and CD16 positive macrophages. A ow cytometry analysis of blood samples was used to detect macrophages with intracellularly tumor cell derived epitopes of biomarkers DNaseX/Apo10 and TKTL1. The increased presence of these biomarkers in macrophages allowed the identication of asymptomatic individuals eligible for further imaging. On subsequent imaging, a high proportion of this pre-selected subgroup showed abnormal tissue structures which are indicative of early cancer stages or pre-malignant structures at high risk for malignancy development. Therefore, the PanTum Detect blood test enables the identication of asymptomatic individuals eligible for imaging.
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